Some hormonal factors linked to the menstrual cycle explain in part why women are more often affected by canker sores than men.
Periods of puberty and menopause seem favourable to canker sores.
Canker sores can happen following the use of some medications, such as:
The following factors have been proven to trigger canker sores:
In some cases, canker sores are linked to other diseases like Behçet's syndrome, Crohn's disease, cancerous ulcerations, PFAPA syndrome, Sweet syndrome, and gluten allergies.